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Tirzepatide (Mounjaro/Zepbound) is a first-in-class dual GIP/GLP-1 receptor agonist FDA-approved for type 2 diabetes and chronic weight management, with up to 22.5% body weight reduction.

Thymosin Alpha-1 (Zadaxin) is an immunomodulatory peptide with FDA orphan drug designation, approved in 35+ countries for hepatitis B/C and immune support, with 400+ human studies.

Tesamorelin (Egrifta/Egrifta WR) is the only FDA-approved GHRH analog for HIV-associated lipodystrophy, demonstrating 18% visceral fat reduction in pivotal trials.

PT-141 (bremelanotide/Vyleesi) is an FDA-approved melanocortin receptor agonist that acts centrally in the brain to treat hypoactive sexual desire disorder in premenopausal women, with significant off-label use for male erectile dysfunction.

Pentosan polysulfate (Elmiron) is an FDA-approved heparinoid for interstitial cystitis with 25+ years of clinical use, also investigated for osteoarthritis and cartilage protection.

PCSK9 inhibitors (alirocumab, evolocumab, inclisiran) are FDA-approved lipid-lowering agents that reduce LDL cholesterol by 50-60% and have proven cardiovascular risk reduction in large outcomes trials.